Relationship between day-by-day blood pressure variability and aortic arch atherosclerosis

Development of an Experimental Model to Study the Relationship Between Day-to-Day Variability in Blood Pressure and Aortic Stiffness

We aimed to develop an animal model of long-term blood pressure variability (BPV) and to investigate its consequences on aortic damage. We hypothesized that day-to-day BPV produced by discontinuous treatment of spontaneously hypertensive rats (SHR) by valsartan may increase arterial stiffness. For that purpose, rats were discontinuously treated, 2 days a week, or continuously treated by valsart...

Day-to-day blood pressure variability and dementia

Day-by-Day Blood Pressure Variability and Functional Outcome After Acute Ischemic Stroke: Fukuoka Stroke Registry.

BACKGROUND AND PURPOSE The relationship between blood pressure (BP) variability and functional outcome in patients with acute ischemic stroke remains unclear. This study aimed to elucidate whether in-hospital day-by-day BP variability is associated with functional outcome after acute ischemic stroke. METHODS Using the Fukuoka Stroke Registry, we included 2566 patients with a first-ever ischem...

Day-by-day blood pressure variability: cause or consequence of vascular brain injury?

D ementia represents an important public health issue in developed countries because of increasing longevity of the elderly population. 1 Cerebral damage is mediated by changes in cerebral vasculature affecting both large and small vessels. 2 The microvascular disease results in chronic ischemic changes affecting the white matter, which in the long run can lead to cognitive alterations, which m...

Day-to-Day Blood Pressure Variability and Risk of Dementia in a General Japanese Elderly Population

BACKGROUND Several observational studies have reported that higher visit-to-visit blood pressure variability is a risk factor for cognitive impairment and dementia. However, no studies have investigated the association of day-to-day blood pressure variability assessed by home blood pressure measurement with the development of dementia. METHODS A total of 1674 community-dwelling Japanese elder...